As the rates of infection and death from COVID-19 have recently declined or stabilized in some areas of the country, many states have established plans for resocialization, and there is an increasing dialogue about the need to balance the economic and other benefits of resocialization and reopening with the need to protect society from the public health consequences of the ongoing spread of COVID-19. Until a vaccine is in place, or until there is effective treatment, this type of balance analysis should continue, with an understanding that the most effective strategy to mitigate COVID-19 spread during resocialization.